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SCIENTISTS DEVELOP NASAL SPRAY THAT IMPROVES MEMORY
ScienceDaily
October 2, 2009
http://www.sciencedaily.com/releases/2009/10/091001091752.htm
Good news for procrastinating students: a nasal spray
developed by a team of German scientists promises to give
late night cram sessions a major boost, if a good night's
sleep follows. In a research report featured as the cover
story of the October 2009 print issue of The FASEB Journal,
these scientists show that a molecule from the body's immune
system (interleukin-6) when administered through the nose
helps the brain retain emotional and procedural memories
during REM sleep.
"Sleep to remember, a dream or reality?" said Lisa Marshall,
co-author of the study, from the Department of
Neuroendocrinology at the University of Lubeck in Germany.
"Here, we provide the first evidence that the
immunoregulatory signal interleukin-6 plays a beneficial role
in sleep-dependent formation of long-term memory in humans."
To make this discovery, Marshall and colleagues had 17
healthy young men spend two nights in the laboratory. On each
night after reading either an emotional or neutral short
story, they sprayed a fluid into their nostrils which
contained either interleukin-6 or a placebo fluid. The
subsequent sleep and brain electric activity was monitored
throughout the night. The next morning subjects wrote down as
many words as they could remember from each of the two
stories. Those who received the dose of IL-6 could remember
more words.
"If a nasal spray can improve memory, perhaps we're on our
way to giving some folks a whiff of common sense, such as
accepting the realities of evolution," said Gerald Weissmann,
M.D., Editor-in-Chief of The FASEB Journal. "This is exciting
piece of interdisciplinary science, since IL-6 had previously
been considered a by-product of inflammation, not an agent
that affects cognition."
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